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Arun: 10 May : 12:36 AM

Hi Priyank, welcome. Feel free to go through these forum threads returned by search [link]

Priyank: 09 May : 10:28 PM

Hi..need advice. What are the options in Australia after MPT?

Arun: 04 Mar : 02:01 AM

Happy birthday Boopathi and somasimple

PTebook: 04 Nov : 09:39 AM

hello everyone!!!!!!!

nibs: 10 Oct : 09:20 AM

Hello everyone


Deep Cortical Stimulation To Promote Neurogenesis And Facilitate Spatial Memory.

Thursday 20 October 2011 - 17:32:25


New studies in animal models show not only that stimulating targeted regions of the brain improves spatial memory but alsodeep_brain_stimulation.jpg that neurogenesis explains, at least in part, this cognitive improvement. Results of these and other experiments provide support for ongoing research into deep brain stimulation (DBS) in patients with Alzheimer's disease (AD).
The possibility of using electrical stimulation to reconstruct damaged circuits in the brain "gives us hope not only of improving symptoms of AD but also of changing the natural course of the illness — slowing it down — and that's quite exciting," one of the study authors, Andres M. Lozano, MD, PhD, senior scientist in the Division of Brain Imaging and Behavior Systems–Neuroscience at the Toronto Western Research Institute, Ontario, Canada, said to Medscape Medical News.
Because other approaches to treating AD such as removing abnormal proteins and increasing acetylcholine in the brain have not been all that successful, researchers are looking to DBS for another treatment option. "We're trying to determine if we can optimize or improve the function of the brain," said Dr. Lozano "Can we enhance the activity and reawaken or reengage brain tissue? In other words, can we somehow coax the brain that is there to work better?" The study was published in the September issue of the Journal of Neuroscience.
In a series of experiments using adult mice, researchers inserted electrodes into the entorhinal cortex of the mice and stimulated this region, which projects directly into the hippocampus, for 1 hour. The stimulation increased production of dentate granule cells. "We showed that that stimulation was sufficient to more or less double the rate of new neuron production," another study author, Paul W. Frankland, PhD, senior scientist at the Hospital for Sick Children, Toronto, said to Medscape Medical News.
Additional experiments showed that the new neurons appeared to mature normally and to integrate into hippocampal networks engaged in spatial memory. "We wanted to make sure that these new neurons were normal ones, so we went to great efforts to show that they grow normally and that they end up in the right place in the circuit," said Dr. Frankland.
Source: [link]

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